Science & Innovation
Imagine a world where…
ALS isn’t a death sentence. Alzheimer’s is reversible. All cancer can be treated without chemotherapy.
A world designed for YOU.
Of the 4000+ protein-linked diseases, we’re only scratching the surface. Over 90% remain untreated, accounting for 40% of US deaths, more than 1.5 million people annually.
Mimerigen is designing the next generation of precision medicine…
Where EVERY LIFE can be saved, EVERY TREATMENT is personalized, and the IMPOSSIBLE BECOMES THE REALITY for millions of people worldwide.
BIOMIMETIC RNA – A BREAKTHROUGH IN RNA THERAPEUTICS
RNA therapeutics holds the potential to unlock treatments for these diseases, but the current solutions – synthetic RNA and traditional synthesis strategies – are far from ideal.
6.9M Americans suffer from Alzhelmer’s today
(10% of adults > 65 YRs)
90% of the 4000 Known protein-linked diseases
Remain untreatbale
40% of us deaths are caused by alzhelmer’s, heart disease.
(~1.5 million annually)
Synthetic rna’s fatal flaws
Why Traditional Approaches Aren’t Enough
LESS SOLUBLE
Chemical modifications can reduce concentration, bioavailability, and cellular uptake.
POOR PROTEIN LOADING
Bulky modifications restrict synthetic RNA from RNAi protein loading.
INCREASED CYTOTOXICTY
Many synthetic RNA are known to be cytotoxic, especially in large doses.
NON-ENZYMATIC SYNTHESIS
Costly (10x), wasteful (200 PMI/base), and inefficient (50% yield, 80% purity).