Application
Synthetic rna’s fatal flaws
Why Traditional Approaches Aren’t Enough
LESS SOLUBLE
Chemical modifications can reduce concentration, bioavailability, and cellular uptake.
POOR PROTEIN LOADING
Bulky modifications restrict synthetic RNA from RNAi protein loading.
INCREASED CYTOTOXICTY
Many synthetic RNA are known to be cytotoxic, especially in large doses.
NON-ENZYMATIC SYNTHESIS
Costly (10x), wasteful (200 PMI/base), and inefficient (50% yield, 80% purity).
We are creating a sustainable platform with targeted applications
Application
- Therapeutics: CNS, cancer, auto-immune, ophthalmic, etc.
- Nanomaterials: Capsules, nanowires, photonic crustals, etc.
- Diagnostics: Ag, Microbiomem precisiondiagnostics, etc.
Modules
- Gene augmentatation: ASOs, siRNA, Crispr guidesm RNAI, etc.
- Macromolecular: Aptamers, ribozymes, origami, “mRNA”, etc.
- Probes: Primers, molecular beacons,m FISH probes, etc.
Platform
- Polymer: Length, chemical modification, & protein interfaces
- Methods: Synthesism monomer production, bioprocess, & scale
- Computaitonal: Structure prediction, Primer design, etc.